Pro-Adrenomedullin (153-185), human

Product Name:Pro-Adrenomedullin (153-185), human

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Molar Mass:3219.6

Chemical Formula:C143H224N42O43

IUPAC Name:(2R)-2-[[(2R)-2-[[(2R)-2-[[1-[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-[[1-[(2R)-1-[(2R)-2-[[(2R)-1-[(2R)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2R)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2R)-1-[2-[[(2S)-2-[[(2S)-2-[[(2R)-1-[(2R)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]acetyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid

SMILES:C[C@@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@H](CC2=CNC=N2)C(=O)NCC(=O)N[C@H](C)C(=O)N3CCC[C@@H]3C(=O)N[C@H](C)C(=O)N4CCC[C@@H]4C(=O)N5CCCC5C(=O)N[C@H](CO)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C)C(=O)N6CCCC6C(=O)N[C@H](CC7=CNC=N7)C(=O)N[C@H](CC8=CC=CC=C8)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H]9CCCN9C(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)N)O

InChIKey:PPXCDLSJHBFXFB-WBUKFPSSSA-N

InChI:InChI=1S/C143H224N42O43/c1-71(2)52-89(171-135(220)113(80(14)191)178-121(206)85(31-20-44-151-143(147)148)163-108(194)62-154-128(213)99-32-21-45-179(99)110(196)63-155-114(199)75(9)159-120(205)87(40-42-111(197)198)166-131(216)103-36-25-49-183(103)140(225)93(53-72(3)4)172-116(201)84(145)64-186)124(209)177-112(74(7)8)134(219)176-98(68-190)127(212)174-97(67-189)126(211)167-88(30-18-19-43-144)139(224)182-48-24-35-102(182)130(215)165-86(39-41-106(146)192)119(204)160-76(10)115(200)168-91(56-82-58-149-69-156-82)117(202)152-60-107(193)158-77(11)136(221)180-46-22-33-100(180)129(214)162-79(13)138(223)185-51-27-38-105(185)141(226)184-50-26-37-104(184)133(218)175-95(65-187)118(203)153-61-109(195)164-96(66-188)125(210)161-78(12)137(222)181-47-23-34-101(181)132(217)170-92(57-83-59-150-70-157-83)123(208)169-90(55-81-28-16-15-17-29-81)122(207)173-94(142(227)228)54-73(5)6/h15-17,28-29,58-59,69-80,84-105,112-113,186-191H,18-27,30-57,60-68,144-145H2,1-14H3,(H2,146,192)(H,149,156)(H,150,157)(H,152,202)(H,153,203)(H,154,213)(H,155,199)(H,158,193)(H,159,205)(H,160,204)(H,161,210)(H,162,214)(H,163,194)(H,164,195)(H,165,215)(H,166,216)(H,167,211)(H,168,200)(H,169,208)(H,170,217)(H,171,220)(H,172,201)(H,173,207)(H,174,212)(H,175,218)(H,176,219)(H,177,209)(H,178,206)(H,197,198)(H,227,228)(H4,147,148,151)/t75-,76-,77+,78+,79+,80-,84-,85-,86-,87-,88-,89-,90+,91+,92+,93+,94+,95+,96+,97-,98-,99+,100+,101,102+,103+,104,105+,112-,113-/m0/s1

Sequence:Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu

Application:Pro-Adrenomedullin (153-185), human is a bioactive peptide fragment derived from pro-adrenomedullin (PAMP), encompassing amino acids 153-185. This peptide is involved in vascular regulation, immune modulation, and metabolic function. Research suggests that PAMP (153-185) exhibits vasodilatory, anti-inflammatory, and antimicrobial properties, making it relevant in cardiovascular, immune, and endocrine studies. It is widely used in hypertension, sepsis, and metabolic disorder research, with potential applications in endothelial function regulation, stress adaptation, and inflammatory disease models. Due to its physiological importance, PAMP (153-185) is a key candidate for therapeutic peptide development.

Current Research:

Introduction
Pro-Adrenomedullin (153-185), human, is a C-terminal fragment derived from pro-adrenomedullin (PAMP), the precursor of adrenomedullin (ADM), a key peptide involved in vasodilation, immune modulation, and metabolic regulation. The 153-185 sequence is of particular interest due to its potential involvement in vascular homeostasis, inflammation control, and endothelial protection. Researchers are investigating PAMP (153-185) as a potential therapeutic target in cardiovascular diseases, immune disorders, and metabolic dysfunctions.

Cardiovascular and Vasodilatory Research
PAMP-derived peptides, including PAMP (153-185), human, have been linked to vascular tone regulation and endothelial function. Research suggests that PAMP (153-185):

Activates nitric oxide (NO) pathways, leading to vasodilation and improved blood flow.
Regulates vascular permeability, reducing the risk of hypertension and endothelial dysfunction.
May have protective effects in ischemic conditions, making it a potential candidate for heart disease and stroke prevention.
These findings highlight PAMP (153-185) as a potential biomarker and therapeutic peptide for cardiovascular diseases.

Immunomodulatory and Anti-Inflammatory Effects
PAMP-derived peptides, including PAMP (153-185), have been studied for their immune-modulating properties, particularly in:

Suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β), helping regulate immune responses.
Enhancing antimicrobial defense mechanisms, suggesting a role in infection control and sepsis research.
Regulating leukocyte activity, which may benefit research on chronic inflammatory conditions and autoimmune diseases.
This peptide’s anti-inflammatory and immune-balancing properties make it relevant in sepsis and inflammatory disease models.

Metabolic and Endocrine Research
PAMP fragments, including PAMP (153-185), have been investigated for their role in metabolism and stress regulation. Studies suggest that:

It may influence glucose metabolism, making it relevant for diabetes and insulin resistance research.
It interacts with stress hormone pathways, potentially affecting adrenal function and metabolic adaptation.
It regulates lipid metabolism, positioning it as a candidate for obesity and cardiovascular risk management.
These findings suggest potential applications of PAMP (153-185) in metabolic syndrome and endocrine dysfunction research.

Potential Research and Therapeutic Applications
Due to its vasodilatory, immune-regulating, and metabolic-stabilizing properties, PAMP (153-185), human, is being explored for:

Cardiovascular disease research, particularly in hypertension and endothelial dysfunction models.
Sepsis and immune-related inflammation studies, focusing on infection-induced cytokine dysregulation.
Metabolic disorder models, including insulin regulation, glucose homeostasis, and lipid metabolism research.
Conclusion
Pro-Adrenomedullin (153-185), human, is a bioactive peptide fragment involved in vascular regulation, immune response, and metabolic homeostasis. Its vasodilatory, anti-inflammatory, and metabolic properties make it a valuable research tool in cardiovascular, immunology, and endocrine studies. Ongoing research continues to explore its therapeutic potential in sepsis, blood pressure regulation, and metabolic disorders, with promising applications in biomarker discovery and peptide-based drug development.