Pro-Adrenomedullin (N-20), rat

Product Name:Pro-Adrenomedullin (N-20), rat

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Molar Mass:2477.9

Chemical Formula:C111H177N37O28

Sequence:Ala-Arg-Leu-Asp-Thr-Ser-Ser-Gln-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2

Application:Pro-Adrenomedullin (N-20), rat is a bioactive peptide fragment derived from the N-terminal region of pro-adrenomedullin (PAMP), consisting of the first 20 amino acids. This peptide is involved in vascular homeostasis, immune modulation, and metabolic regulation. Studies suggest that PAMP (N-20) in rats exhibits vasodilatory, antimicrobial, and anti-inflammatory properties, making it a key research tool in cardiovascular function, sepsis, and endocrine studies. It is widely used in hypertension, immune modulation, and endothelial function research, with potential applications in inflammatory disease models, metabolic disorders, and neuroendocrine regulation in rat-based studies.

Current Research:

Introduction
Pro-Adrenomedullin (N-20), rat, is a truncated peptide fragment derived from pro-adrenomedullin (PAMP), which serves as the precursor for adrenomedullin (ADM), a potent vasodilatory peptide. The N-terminal region of PAMP (N-20) retains significant bioactivity, particularly in cardiovascular, immune, and metabolic regulation. In rat models, this peptide is widely studied for its potential effects on vascular tone, immune function, and metabolic homeostasis, making it an essential tool for translational research.

Cardiovascular and Vasodilatory Research
Pro-adrenomedullin-derived peptides, including PAMP (N-20), rat, have been associated with vascular homeostasis and blood pressure regulation. Research findings suggest:

Endothelial nitric oxide (NO) synthesis activation, leading to vasodilation and blood pressure reduction.
Regulation of vascular tone, impacting hypertension and endothelial dysfunction.
Potential anti-hypertensive effects, with implications for cardiovascular disease research in rat models.
These findings support its investigation in preclinical models of cardiovascular disorders and hypertension.

Immunomodulatory and Anti-Inflammatory Effects
PAMP (N-20) has been linked to immune response regulation, with studies focusing on:

Suppression of pro-inflammatory cytokine release, including TNF-α, IL-6, and IL-1β.
Modulation of immune cell function, particularly macrophages and T-cells, impacting immune responses to infections.
Protective effects in sepsis and systemic inflammatory response syndrome (SIRS), where PAMP-derived peptides may help control excessive inflammation.
Given these effects, PAMP (N-20) is being explored in rat models of immune-mediated diseases.

Metabolic and Endocrine Research
Studies on PAMP and its fragments suggest roles in metabolism and stress hormone regulation. Research findings in rat models indicate:

Potential insulin-regulating properties, making it a candidate for diabetes and metabolic syndrome studies.
Interactions with adrenal hormone pathways, suggesting links to stress regulation and energy balance.
These effects position PAMP (N-20) as a target for metabolic and neuroendocrine disorder research in rat-based studies.

Potential Research and Therapeutic Applications
Due to its vasodilatory, anti-inflammatory, and immune-regulating properties, PAMP (N-20), rat is being explored for:

Cardiovascular disease research, focusing on hypertension and endothelial function.
Sepsis and infection-related inflammatory responses, particularly in immune-mediated conditions.
Metabolic disorder models, including insulin regulation and glucose metabolism studies.
Conclusion
Pro-Adrenomedullin (N-20), rat, is a bioactive peptide fragment involved in vascular regulation, immune modulation, and metabolic control. Its vasodilatory, anti-inflammatory, and potential metabolic effects make it a valuable tool in cardiovascular, immunology, and endocrine research. Ongoing studies continue to explore its therapeutic potential in blood pressure regulation, infection response, and metabolic disorders in preclinical rat models.