Spike protein (S2) SARS-CoV-2 substrate

Product Name: Spike protein (S2) SARS-CoV-2 substrate

Sequence One Letter Code: QXL®520-SKPSKRSFIED-K(5-FAM)-NH2

Sequence Three Letter Code: QXL®520-Ser-Lys-Pro-Ser-Lys-Arg-Ser-Phe-Ile-Glu-Asp-Lys(5-FAM)-OH

Molecular Weight: 2270.4

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C Protected from light

Source / Species: SARS-CoV-2

Conjugation: Conjugated

Conjugation Type: Double dyes

Code Nacres: NA.26

Application: SARS-CoV-2 Spike S2 Furin-like Cleavage Site FRET Substrate is a synthetic peptide representing the second furin-like cleavage site within the SARS-CoV-2 spike protein S2 region. The conserved KR↓SF motif contains key basic and hydrophobic residues involved in proteolytic activation and is identical in SARS-CoV-2 and SARS-CoV. Labeled with QXL®520 and 5-FAM as a FRET pair, this peptide enables sensitive monitoring of protease cleavage activity. It is widely used in studies of spike protein processing, viral entry mechanisms, protease kinetics, inhibitor screening, and antiviral research targeting spike activation.