Tat-NR2Bct

Product Name: Tat-NR2Bct

Sequence One Letter Code: YGRKKRRQRRRKLSSIESDV

Sequence Three Letter Code: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val-OH

Chemical Formula:C105H188N42O30

Molecular Weight: 2519

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: HIV

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Tat-NR2Bct is a membrane-permeable decoy peptide designed to disrupt the interaction between the NMDA receptor NR2B subunit and postsynaptic density protein PSD-95. It combines the HIV-Tat transduction domain with the C-terminal PSD-95-binding motif of NR2B, enabling efficient neuronal uptake. By interfering with NR2B–PSD-95 coupling, Tat-NR2Bct modulates synaptic signaling without directly blocking NMDA receptor ion conductance. This peptide is widely used in neuroscience research to study excitotoxicity, synaptic plasticity, neuroprotective signaling, NMDA receptor-associated pathways, and mechanisms of neuronal injury or survival.