[Thr28, Nle31]-Cholecystokinin (25-33), sulfated CCK-9

Product Name: [Thr28, Nle31]-Cholecystokinin (25-33), sulfated CCK-9

Sequence One Letter Code: RD-Y(SO3H)-TGW-Nle-DF-NH2

Sequence Three Letter Code: H-Arg-Asp-Tyr(SO3H)-Thr-Gly-Trp-Nle-Asp-Phe-NH2

Cas No: 77568-41-3

Chemical Formula:C55H74N14O18S

Molecular Weight: 1251.4

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: CCCC[C@@H](C(=O)N[C@@H](CC(=O)OS(=O)(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN=C(N)N)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)N

IUPAC: (3S)-3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-4-oxo-4-sulfooxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid

INCHIKEY: PBHKFCLZCVGPRU-VCCAZEROSA-N

INCHI:

InChI=1S/C55H74N14O18S/c1-3-4-15-38(64-50(79)40(24-32-27-61-37-16-9-8-13-34(32)37)63-43(72)28-62-54(83)46(29(2)70)68-48(77)36(57)22-31-17-19-33(71)20-18-31)49(78)67-42(26-45(75)87-88(84,85)86)51(80)66-39(23-30-11-6-5-7-12-30)52(81)69-53(82)41(25-44(73)74)65-47(76)35(56)14-10-21-60-55(58)59/h5-9,11-13,16-20,27,29,35-36,38-42,46,61,70-71H,3-4,10,14-15,21-26,28,56-57H2,1-2H3,(H,62,83)(H,63,72)(H,64,79)(H,65,76)(H,66,80)(H,67,78)(H,68,77)(H,73,74)(H4,58,59,60)(H,69,81,82)(H,84,85,86)/t29-,35+,36+,38+,39+,40+,41+,42+,46+/m1/s1

Source / Species: Human, mouse, rat

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Stabilized CCK-8 Analog is a modified cholecystokinin peptide that retains the full bioactivity of sulfated CCK-8 while exhibiting enhanced resistance to acidic degradation and oxidation. Substitution of Thr28 and norleucine at position 31 for methionine improves peptide stability without compromising receptor activation. This analog adopts a predominant conformation featuring a gamma-turn and C-terminal helical segment important for biological function. Stabilized CCK-8 Analog is widely used in gastrointestinal hormone research, satiety signaling studies, CCK receptor pharmacology, metabolic research, and experiments requiring robust, stable cholecystokinin ligands.