Product Name:Vialox (Pentapeptide-3V)
Purity:95%
Chemical Formula:C21H36N8O6
Molar Mass:496.6
Synonyms:SCHEMBL1552457
IUPAC Name:(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
SMILES:C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CCCN2C(=O)CN
InChIKey:DSKKBQQWWJESHK-AJNGGQMLSA-N
InChI:InChI=1S/C21H36N8O6/c1-12(20(34)35)26-17(31)15-7-4-10-29(15)19(33)13(5-2-8-25-21(23)24)27-18(32)14-6-3-9-28(14)16(30)11-22/h12-15H,2-11,22H2,1H3,(H,26,31)(H,27,32)(H,34,35)(H4,23,24,25)/t12-,13-,14-,15-/m0/s1
Storage:-20 degree Celsius
Sequence:GPRPA
Application:
Vialox™ (Pentapeptide-3V) is a synthetic botulinum-like peptide designed to reduce expression lines and dynamic wrinkles by modulating muscle contraction at the neuromuscular junction. Composed of a five-amino-acid sequence, Vialox mimics the activity of natural neuroinhibitory peptides, decreasing acetylcholine release and softening facial microtension. It is clinically studied for smoothing forehead lines, crow’s feet, and glabellar folds without the need for injections. Vialox is widely used in anti-aging creams, serums, and eye treatments, offering a gentle, topical alternative to botulinum toxin for visible wrinkle reduction and facial relaxation.
Current Research:
Introduction: What Is Vialox (Pentapeptide-3V)?
Vialox™, also known as Pentapeptide-3V, is a bioengineered peptide developed to mimic the neuromuscular-relaxing effects of botulinum toxin, but in a non-invasive, topical form. It is designed to act on the same pathway as Botox—blocking neurotransmitter release at the neuromuscular junction—to prevent excessive facial muscle contraction, one of the main contributors to expression wrinkles.
Its five-amino-acid sequence is modeled after peptides that naturally interfere with muscle excitation, particularly by modulating sodium ion channels and acetylcholine signaling.
Mechanism of Action: Neuromuscular Relaxation
Vialox targets the neuromuscular communication pathway, specifically:
Inhibiting acetylcholine release at motor nerve endings
Reducing muscle excitability and facial tension
Preventing repetitive microcontractions that lead to wrinkle formation
By modulating voltage-gated sodium channels, it lowers the firing potential of muscle-innervating neurons, resulting in a gentle muscle-relaxing effect without paralysis or long-term blockage.
This biochemical mechanism leads to smoother skin appearance, particularly in dynamic areas affected by repetitive movement (e.g., forehead, eyes, mouth).
Clinical Benefits in Wrinkle Reduction
In cosmetic studies, Vialox has shown:
Up to 49% reduction in wrinkle depth after 28 days of daily use
Significant improvement in skin smoothness
Noticeable softening of crow’s feet and frown lines
Enhanced skin tone and texture around expression-prone areas
Unlike injectables, Vialox works gradually, with optimal results appearing after 2–4 weeks of consistent topical application. It is especially appealing for individuals seeking non-invasive cosmetic solutions or looking to extend the effects of botulinum injections between treatments.
Use in Cosmetic Formulations
Vialox is incorporated into a variety of anti-aging skincare products, including:
Eye contour creams
Wrinkle-relief serums
Lifting and firming masks
Daily moisturizers
It is stable in aqueous formulations, compatible with common ingredients like hyaluronic acid, peptides, niacinamide, and vitamin C, and typically used at concentrations of 2–5% depending on formulation goals.
Safety and Skin Compatibility
Vialox has been evaluated in clinical and in vitro dermatological studies, demonstrating:
High biocompatibility
No irritation or sensitization in human subjects
No cytotoxicity to dermal fibroblasts or keratinocytes
Safe for daily, long-term use
It is suitable for all skin types, including sensitive and mature skin, and can be used alongside chemical exfoliants or retinoids for a multi-modal anti-aging routine.
Applications Beyond Wrinkle Reduction
While Vialox is primarily studied for wrinkle smoothing, it also contributes to:
Facial relaxation and reduction of muscle-induced skin fatigue
Improved dermal matrix remodeling when combined with collagen-boosting agents
Support in skin texture refinement and hydration balance
Its neuromodulatory action provides subtle improvements in overall skin quality, especially in areas prone to repetitive movement or facial tension.
Conclusion
Vialox (Pentapeptide-3V) is a modern cosmetic peptide that offers targeted muscle relaxation through topical application, helping to reduce dynamic wrinkles and soften facial expression lines. With a gentle, Botox-like mechanism and excellent safety profile, it is a valuable ingredient in non-invasive anti-aging skincare. Its ability to relax facial tension while supporting skin renewal makes it an ideal component of advanced wrinkle-correction and skin-smoothing protocols.
Reference:
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