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Cell Penetrating Peptides

Efficient Intracellular Delivery Tools for Biomolecules and Therapeutics

Overview

Cell penetrating peptides (CPPs) are short peptides capable of crossing cellular membranes and facilitating the intracellular delivery of various cargoes, including peptides, proteins, nucleic acids, and small molecules. Due to their versatility and efficiency, CPPs are widely used in drug delivery and cellular uptake studies. At LinkPeptide, we offer a diverse range of CPPs optimized for reliable delivery performance across different biological systems. Each peptide is synthesized under strict quality control to ensure consistency and reproducibility in experimental applications.

Mechanism of Action

CPPs enable cellular entry through multiple mechanisms depending on their structure and the biological context. These mechanisms typically include:
  1. Direct translocation across the lipid bilayer
  2. Endocytosis-mediated cellular uptake
  3. Electrostatic interaction with cell membranes
  4. Cargo complex formation for enhanced intracellular delivery
These pathways allow efficient transport of biomolecules into cells for functional and mechanistic studies.

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PTD-DBM

PTD-DBM

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R8-T198wt

R8-T198wt

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TAT 14

TAT 14

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TAT-cyclo-CLLFVY
TAT-Gap19

TAT-Gap19

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Applications

Cell penetrating peptides are widely applied in:

Drug Delivery Research

Facilitating intracellular transport of therapeutic molecules and improving delivery efficiency

Gene Delivery Studies

Delivering nucleic acids such as siRNA, mRNA, and plasmids into cells

Cellular Uptake Analysis

Investigating membrane translocation mechanisms and intracellular trafficking

Imaging & Localization Studies

Tracking peptide distribution using labeled CPPs in live or fixed cells

Functional Biology Studies

Delivering bioactive molecules to modulate intracellular pathways

Why Choose LinkPeptide

  1. High purity peptides for consistent delivery performance
  2. Wide range of CPP sequences and formats available
  3. Custom conjugation and labeling services
  4. Reliable synthesis with strict quality control standards
Our CPPs are designed to support efficient and reproducible intracellular delivery across diverse experimental systems.

Supporting Resources

  1. Selecting CPPs for Intracellular Applications
  2. Advances in Peptide-Based Delivery Systems
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